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74 results

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Page 1
CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation.
Chen J, Ding Y, Jiang C, Qu R, Wren JD, Georgescu C, Wang X, Reuter DN, Liu B, Giles CB, Mayr CH, Schiller HB, Dai J, Stipp CS, Subramaniyan B, Wang J, Zuo H, Huang C, Fung KM, Rice HC, Sonnenberg A, Wu D, Walters MS, Zhao YY, Kanie T, Hays FA, Papin JF, Wang DW, Zhang XA. Chen J, et al. Circ Res. 2024 Apr 1. doi: 10.1161/CIRCRESAHA.123.323190. Online ahead of print. Circ Res. 2024. PMID: 38557119
BACKGROUND: Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role in vascular inflammation remains largely unknown. ...By supporting protein quality control and protein degradation, CD151 prevents proteins from (1) bui …
BACKGROUND: Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role in vascular inflamm …
Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension.
Zhang F, Michaelson JE, Moshiach S, Sachs N, Zhao W, Sun Y, Sonnenberg A, Lahti JM, Huang H, Zhang XA. Zhang F, et al. Blood. 2011 Oct 13;118(15):4274-84. doi: 10.1182/blood-2011-03-339531. Epub 2011 Aug 10. Blood. 2011. PMID: 21832275 Free PMC article.
However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular functions are unclear. ...In addition, vascular permeability is markedly enhanced in the absence of CD151. ...
However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular f …
CD151 is associated with prostate cancer cell invasion and lymphangiogenesis in vivo.
Detchokul S, Newell B, Williams ED, Frauman AG. Detchokul S, et al. Oncol Rep. 2014 Jan;31(1):241-7. doi: 10.3892/or.2013.2823. Epub 2013 Oct 29. Oncol Rep. 2014. PMID: 24174171
These roles involve association with integrins on both cell-cell and cell-stroma levels. Furthermore, CD151 plays a role in endothelial cell motility. CD151 expression was examined in three commonly used prostate cancer cell lines. ...We identified, for the first ti …
These roles involve association with integrins on both cell-cell and cell-stroma levels. Furthermore, CD151 plays a role in endotheli …
JAM-A interacts with alpha3beta1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells.
Thölmann S, Seebach J, Otani T, Florin L, Schnittler H, Gerke V, Furuse M, Ebnet K. Thölmann S, et al. Cell Mol Life Sci. 2022 Jan 24;79(2):88. doi: 10.1007/s00018-022-04140-5. Cell Mol Life Sci. 2022. PMID: 35067832 Free PMC article.
Mapping experiments indicate that JAM-A associates with alpha3beta1 integrin and tetraspanins CD151 and CD9 through its extracellular domain. Similar to depletion of JAM-A, depletion of either alpha3beta1 integrin or tetraspanins CD151 and CD9 in MDCK cells slows do …
Mapping experiments indicate that JAM-A associates with alpha3beta1 integrin and tetraspanins CD151 and CD9 through its extracellular …
Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma.
Ke AW, Shi GM, Zhou J, Wu FZ, Ding ZB, Hu MY, Xu Y, Song ZJ, Wang ZJ, Wu JC, Bai DS, Li JC, Liu KD, Fan J. Ke AW, et al. Hepatology. 2009 Feb;49(2):491-503. doi: 10.1002/hep.22639. Hepatology. 2009. PMID: 19065669
However, the role of CD151 alone and coexpression of CD151/c-Met in hepatocellular carcinoma (HCC) remains unclear. ...Furthermore, HCC patients with vascular invasion, large tumors, multiple tumors, high tumor-node-metastasis stage, and undifferentiated tumo …
However, the role of CD151 alone and coexpression of CD151/c-Met in hepatocellular carcinoma (HCC) remains unclear. ...Further …
CD151 modulates expression of matrix metalloproteinase 9 and promotes neoangiogenesis and progression of hepatocellular carcinoma.
Shi GM, Ke AW, Zhou J, Wang XY, Xu Y, Ding ZB, Devbhandari RP, Huang XY, Qiu SJ, Shi YH, Dai Z, Yang XR, Yang GH, Fan J. Shi GM, et al. Hepatology. 2010 Jul;52(1):183-96. doi: 10.1002/hep.23661. Hepatology. 2010. PMID: 20578262
The postoperative 3-, 5-, and 7-year overall survival rates of HCC patients with CD151(high)/MMP9(high)/MVD(high) were significantly lower than those of the CD151(low)/MMP9(low)/MVD(low) group or groups in which only one or two of CD151, MMP9, and MVD were hi …
The postoperative 3-, 5-, and 7-year overall survival rates of HCC patients with CD151(high)/MMP9(high)/MVD(high) were significantly …
Tetraspanins CD9 and CD151 at the immune synapse support T-cell integrin signaling.
Rocha-Perugini V, González-Granado JM, Tejera E, López-Martín S, Yañez-Mó M, Sánchez-Madrid F. Rocha-Perugini V, et al. Eur J Immunol. 2014 Jul;44(7):1967-75. doi: 10.1002/eji.201344235. Epub 2014 Apr 29. Eur J Immunol. 2014. PMID: 24723389 Free PMC article.
CD9 or CD151 silencing diminishes the relocalization of alpha4beta1 integrin to the IS and reduces the accumulation of high-affinity beta1 integrins at the cell-cell contact. These changes are accompanied by diminished phosphorylation of the integrin downstream targets FAK …
CD9 or CD151 silencing diminishes the relocalization of alpha4beta1 integrin to the IS and reduces the accumulation of high-affinity …
The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding.
Yue S, Mu W, Erb U, Zöller M. Yue S, et al. Oncotarget. 2015 Feb 10;6(4):2366-84. doi: 10.18632/oncotarget.2958. Oncotarget. 2015. PMID: 25544774 Free PMC article.
Tspan8 and CD151 are metastasis-promoting tetraspanins and a knockdown (kd) of Tspan8 or CD151 and most pronounced of both tetraspanins affects the metastatic potential of the rat pancreatic adenocarcinoma line ASML. ...These effects are not seen or are weakened usi …
Tspan8 and CD151 are metastasis-promoting tetraspanins and a knockdown (kd) of Tspan8 or CD151 and most pronounced of both tet …
Distorted leukocyte migration, angiogenesis, wound repair and metastasis in Tspan8 and Tspan8/CD151 double knockout mice indicate complementary activities of Tspan8 and CD51.
Zhao K, Erb U, Hackert T, Zöller M, Yue S. Zhao K, et al. Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):379-391. doi: 10.1016/j.bbamcr.2017.11.007. Epub 2017 Nov 11. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29138006 Free article.
However, delayed type hypersensitivity reactions are mitigated in Tspan8ko mice, angiogenesis is severely impaired in Tspan8ko, CD151ko and dbko mice, with Tspan8 mostly affecting lymphangiogenesis. Distinct contributions of CD151 and Tspan8 to skin wound healing rely on p …
However, delayed type hypersensitivity reactions are mitigated in Tspan8ko mice, angiogenesis is severely impaired in Tspan8ko, CD151ko and …
CD151 regulates tumorigenesis by modulating the communication between tumor cells and endothelium.
Sadej R, Romanska H, Baldwin G, Gkirtzimanaki K, Novitskaya V, Filer AD, Krcova Z, Kusinska R, Ehrmann J, Buckley CD, Kordek R, Potemski P, Eliopoulos AG, Lalani el-N, Berditchevski F. Sadej R, et al. Mol Cancer Res. 2009 Jun;7(6):787-98. doi: 10.1158/1541-7786.MCR-08-0574. Epub 2009 Jun 16. Mol Cancer Res. 2009. PMID: 19531562 Free article.
Stable down-regulation of this tetraspanin by short-hairpin RNA decreased the tumorigenicity of these cells in mice. Detailed immunohistologic analysis of CD151(+) and CD151(-) xenografts showed differences in tumor vascular pattern. Vascularization ob …
Stable down-regulation of this tetraspanin by short-hairpin RNA decreased the tumorigenicity of these cells in mice. Detailed immunohistolog …
74 results